Quest Insight Variant Classification Program

Laboratories report a variant of unknown significance (VUS) when a genetic difference is identified and there is currently not enough information to know whether this difference is associated with a higher risk for cancer or if this difference is due to normal variation.

Quest Diagnostics uses the following criteria to classify variants as benign or pathogenic:  frequency in the general population, co-occurrence with pathogenic mutations, functional studies, clinical presentation and segregation of symptoms with disease in families.  This information is collected from internal data, public databases and peer-reviewed literature.  Your participation in Quest Insight can enhance this classification process by helping collect segregation data from this family. Through this program, one or more family members may qualify for testing for the VUS identified in your patient.

It is important to note, participation in Quest Insight does not guarantee VUS reclassification. Participation of family members in Quest Insight should also not replace genetic counseling and/or clinically indicated genetic testing.

If your patient is interested in participating in Quest Insight, please contact Quest Genomics Client Services at 1-866-GENE-INFO (436-3463) and ask to speak with an Oncology Genetic Counselor.

Please note, if the VUS is reclassified, Quest Diagnostics will endeavor to contact you. Since we cannot predict if or when this reclassification will occur, it is important for your patient to remain in contact with your office to ensure s/he can also be notified of any change in the interpretation of the VUS.

If you have any questions about Quest Insight, please contact Quest Genomics Client Services at 1-866-GENE-INFO (436-3463) and ask to speak with an Oncology Genetic Counselor.